Publikationen

Publikationen mit Beteiligung der Core Facility Genomics (Transkriptom-, Mikroarrayanalyse):

  • Weiner F, Schille JT, Koczan D, Wu XF, Beller M, Junghanss C, Hewicker-Trautwein M, Murua Escobar H, Nolte I. Novel chemotherapeutic agent FX-9activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line. BMC Cancer. 2021 Oct 8;21(1):1088. doi:10.1186/s12885-021-08836-y. PMID: 34625047.
  • Yenuganti VR, Koczan D, Vanselow J. Genome wide effects of oleic acid oncultured bovine granulosa cells: evidence for the activation of pathwaysfavoring folliculo-luteal transition. BMC Genomics. 2021 Jun 29;22(1):486. doi:10.1186/s12864-021-07817-6. Erratum in: BMC Genomics. 2021 Aug 24;22(1):628.PMID: 34187362; PMCID: PMC8243882.
  • Riess C, Koczan D, Schneider B, Linke C, Del Moral K, Classen CF, Maletzki C.Cyclin-dependent kinase inhibitors exert distinct effects on patient-derived 2Dand 3D glioblastoma cell culture models. Cell Death Discov. 2021 Mar 15;7(1):54.doi: 10.1038/s41420-021-00423-1. PMID: 33723248; PMCID: PMC7961149.
  • Kowtharapu BS, Damaraju J, Singh NK, Ziebart J, Bader R, Koczan D, Stachs O.Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields. Genes(Basel). 2021 Feb 20;12(2):299. doi: 10.3390/genes12020299. PMID: 33672614;PMCID: PMC7924190.
  • Samaha E, Vierlinger K, Weinhappel W, Godnic-Cvar J, Nöhammer C, Koczan D,Thiesen HJ, Yanai H, Fraifeld VE, Ziesche R. Expression Profiling Suggests Lossof Surface Integrity and Failure of Regenerative Repair as Major Driving Forcesfor Chronic Obstructive Pulmonary Disease Progression. Am J Respir Cell Mol Biol. 2021 Apr;64(4):441-452. doi: 10.1165/rcmb.2020-0270OC. PMID: 33524306.
  • Vasudevan P, Wolfien M, Lemcke H, Lang CI, Skorska A, Gaebel R, Koczan D, Lindner T, Engelmann R, Vollmar B, Krause BJ, Wolkenhauer O, Lang H, Steinhoff G, David R. Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells. 2020 Aug 3;9(8):1825. doi:10.3390/cells9081825. PMID: 32756334; PMCID: PMC7465503.
  • Staehlke S, Haack F, Waldner AC, Koczan D, Moerke C, Mueller P, Uhrmacher AM, Nebe JB. ROS Dependent Wnt/β-Catenin Pathway and Its Regulation on Defined Micro-Pillars-A Combined In Vitro and In Silico Study. Cells. 2020 Jul 27;9(8):1784. doi: 10.3390/cells9081784. PMID: 32726949; PMCID: PMC7464713.
  • Köhler J, Maletzki C, Koczan D, Frank M, Springer A, Steffen C, Revenko AS, MacLeod AR, Mikkat S, Kreikemeyer B, Oehmcke-Hecht S. Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis. EBioMedicine. 2020 Aug;58:102908. doi: 10.1016/j.ebiom.2020.102908. Epub 2020 Jul 21. PMID: 32707450; PMCID: PMC7381504.
  • Polei M, Günther J, Koczan D, Fürbass R. Gene expression profiles of bovine uninucleate trophoblast cells and trophoblast giant cells: a data note. BMC Res Notes. 2020 Feb 27;13(1):115. doi: 10.1186/s13104-020-04964-z. PMID: 32103781; PMCID: PMC7045614.
  • Mueller P, Wolfien M, Ekat K, Lang CI, Koczan D, Wolkenhauer O, Hahn O, Peters K, Lang H, David R, Lemcke H. RNA-Based Strategies for Cardiac Reprogramming of Human Mesenchymal Stromal Cells. Cells. 2020 Feb 22;9(2):504. doi: 10.3390/cells9020504. PMID: 32098400; PMCID: PMC7072829.
  • Hahn O, Ingwersen LC, Soliman A, Hamed M, Fuellen G, Wolfien M, Scheel J, Wolkenhauer O, Koczan D, Kamp G, Peters K. TGF-ß1 Induces Changes in the Energy Metabolism of White Adipose Tissue-Derived Human Adult Mesenchymal Stem/Stromal Cells In Vitro. Metabolites. 2020 Feb 7;10(2):59. doi: 10.3390/metabo10020059. PMID: 32046088; PMCID: PMC7074410.
  • Polei M, Günther J, Koczan D, Fürbass R. Trophoblast cell differentiation in the bovine placenta: differentially expressed genes between uninucleate trophoblast cells and trophoblast giant cells are involved in the composition and remodeling of the extracellular matrix and O-glycan biosynthesis. BMC Mol Cell Biol. 2020 Jan 17;21(1):1. doi: 10.1186/s12860-020-0246-8. PMID: 31952476; PMCID: PMC6969411.
  • Seemann S, Ernst M, Cimmaruta C, Struckmann S, Cozma C, Koczan D, Knospe AM, Haake LR, Citro V, Bräuer AU, Andreotti G, Cubellis MV, Fuellen G, Hermann A, Giese AK, Rolfs A, Lukas J. Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease. Biochem J. 2020 Jan 31;477(2):359-380. doi: 10.1042/BCJ20190513. PMID: 31899485; PMCID: PMC6993862.
  • Köhler J, Maletzki C, Koczan D, Frank M, Trepesch C, Revenko AS, Crosby JR, Macleod AR, Mikkat S, Oehmcke-Hecht S. The contact system proteases play disparate roles in streptococcal sepsis. Haematologica. 2020 May;105(5):1424-1435. doi: 10.3324/haematol.2019.223545. Epub 2019 Jul 18. PMID: 31320552; PMCID: PMC7193472.
  • Baufeld A, Koczan D, Vanselow J. L-lactate induces specific genome wide alterations of gene expression in cultured bovine granulosa cells. BMC Genomics. 2019 Apr 5;20(1):273. doi: 10.1186/s12864-019-5657-6. PMID: 30953450; PMCID: PMC6451254.
  • Vlachavas EI, Pilalis E, Papadodima O, Koczan D, Willis S, Klippel S, Cheng C, Pan L, Sachpekidis C, Pintzas A, Gregoriou V, Dimitrakopoulou-Strauss A, Chatziioannou A. Radiogenomic Analysis of F-18-Fluorodeoxyglucose Positron Emission Tomography and Gene Expression Data Elucidates the Epidemiological Complexity of Colorectal Cancer Landscape. Comput Struct Biotechnol J. 2019 Jan 25;17:177-185. doi: 10.1016/j.csbj.2019.01.007. PMID: 30809322; PMCID: PMC6374701.
  • Hecker M, Boxberger N, Illner N, Fitzner B, Schröder I, Winkelmann A, Dudesek A, Meister S, Koczan D, Lorenz P, Thiesen HJ, Zettl UK. A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene. PLoS Genet. 2019 Feb 7;15(2):e1007961. doi: 10.1371/journal.pgen.1007961. PMID: 30730892; PMCID: PMC6382214.
  • Maruschke M, Koczan D, Ziems B, Hakenberg OW. Copy Number Alterations with Prognostic Potential in Clear Cell Renal Cell Carcinoma. Urol Int. 2018;101(4):417-424. doi: 10.1159/000493149. Epub 2018 Sep 18. PMID: 30227442.
  • Baddela VS, Sharma A, Viergutz T, Koczan D, Vanselow J. Low Oxygen Levels Induce Early Luteinization Associated Changes in Bovine Granulosa Cells. Front Physiol. 2018 Aug 7;9:1066. doi: 10.3389/fphys.2018.01066. PMID: 30131718; PMCID: PMC6090175.
  • Koczan D, Fitzner B, Zettl UK, Hecker M. Microarray data of transcriptome shifts in blood cell subsets during S1P receptor modulator therapy. Sci Data. 2018 Jul 24;5:180145. doi: 10.1038/sdata.2018.145. PMID: 30040082; PMCID: PMC6057441.
  • Holzmann C, Saager C, Mechtersheimer G, Koczan D, Helmke BM, Bullerdiek J. Malignant transformation of uterine leiomyoma to myxoid leiomyosarcoma after morcellation associated with ALK rearrangement and loss of 14q. Oncotarget. 2018 Jun 12;9(45):27595-27604. doi: 10.18632/oncotarget.25137. PMID: 29963223; PMCID: PMC6021249.
  • Baddela VS, Sharma A, Koczan D, Viergutz T, Vernunft A, Vanselow J. mRNA microarray data of FACS purified bovine small and large luteal cells. Data Brief. 2018 May 24;19:737-742. doi: 10.1016/j.dib.2018.05.029. PMID: 29900371; PMCID: PMC5997839.
  • Kowtharapu BS, Prakasam RK, Murín R, Koczan D, Stahnke T, Wree A, Jünemann AGM, Stachs O. Role of Bone Morphogenetic Protein 7 (BMP7) in the Modulation of Corneal Stromal and Epithelial Cell Functions. Int J Mol Sci. 2018 May 9;19(5):1415. doi: 10.3390/ijms19051415. PMID: 29747422; PMCID: PMC5983782.
  • Baddela VS, Koczan D, Viergutz T, Vernunft A, Vanselow J. Global gene expression analysis indicates that small luteal cells are involved in extracellular matrix modulation and immune cell recruitment in the bovine corpus luteum. Mol Cell Endocrinol. 2018 Oct 15;474:201-213. doi: 10.1016/j.mce.2018.03.011. Epub 2018 Mar 27. PMID: 29596969.
  • Schäffler H, Rohde M, Rohde S, Huth A, Gittel N, Hollborn H, Koczan D, Glass Ä, Lamprecht G, Jaster R. NOD2 - and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn's disease patients. World J Gastroenterol. 2018 Mar 21;24(11):1196-1205. doi: 10.3748/wjg.v24.i11.1196. PMID: 29568200; PMCID: PMC5859222.
  • Michaelis M, Sobczak A, Koczan D, Langhammer M, Reinsch N, Schön J, Weitzel JM. Testicular transcriptional signatures associated with high fertility. Reproduction. 2018 Feb;155(2):219-231. doi: 10.1530/REP-17-0392. PMID: 29382704.
  • Angerer IC, Hecker M, Koczan D, Roch L, Friess J, Rüge A, Fitzner B, Boxberger N, Schröder I, Flechtner K, Thiesen HJ, Winkelmann A, Meister S, Zettl UK. Transcriptome profiling of peripheral blood immune cell populations in multiple sclerosis patients before and during treatment with a sphingosine-1-phosphate receptor modulator. CNS Neurosci Ther. 2018 Mar;24(3):193-201. doi: 10.1111/cns.12793. Epub 2018 Jan 3. PMID: 29314605; PMCID: PMC6490155.
  • Michaelis M, Sobczak A, Koczan D, Langhammer M, Reinsch N, Schoen J, Weitzel JM. Selection for female traits of high fertility affects male reproductive performance and alters the testicular transcriptional profile. BMC Genomics. 2017 Nov 21;18(1):889. doi: 10.1186/s12864-017-4288-z. PMID: 29157197; PMCID: PMC5697431.
  • Galow AM, Rebl A, Koczan D, Bonk SM, Baumann W, Gimsa J. Increased osteoblast viability at alkaline pH in vitro provides a new perspective on bone regeneration. Biochem Biophys Rep. 2017 Feb 27;10:17-25. doi: 10.1016/j.bbrep.2017.02.001. PMID: 28955732; PMCID: PMC5614624.
  • Markus-Koch A, Schmitt O, Seemann S, Lukas J, Koczan D, Ernst M, Fuellen G, Wree A, Rolfs A, Luo J. ADAM23 promotes neuronal differentiation of human neural progenitor cells. Cell Mol Biol Lett. 2017 Aug 18;22:16. doi: 10.1186/s11658-017-0045-1. PMID: 28828010; PMCID: PMC5562998.
  • Galow AM, Rebl A, Koczan D, Gimsa J. MC3T3 osteoblast-like cells cultured at alkaline pH: Microarray data (Affymetrix GeneChip Mouse 2.0 ST). Data Brief. 2017 May 10;13:108-114. doi: 10.1016/j.dib.2017.05.013. PMID: 28580407; PMCID: PMC5447371.
  • Thiesen HJ, Steinbeck F, Maruschke M, Koczan D, Ziems B, Hakenberg OW. Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene- directed copy number alteration (CNA) analysis. PLoS One. 2017 May 9;12(5):e0176659. doi: 10.1371/journal.pone.0176659. PMID: 28486536; PMCID: PMC5423597.
  • Holzmann C, Koczan D, Loening T, Rommel B, Bullerdiek J. Case Report: A Low- grade Uterine Leiomyosarcoma Showing Multiple Genetic Aberrations Including a Bi-allelic Loss of the Retinoblastoma Gene Locus, as well as Germ-line Uniparental Disomy for Part of the Long Arm of Chromosome 22. Anticancer Res. 2017 May;37(5):2233-2237. doi: 10.21873/anticanres.11559. PMID: 28476787.
  • Bloch J, Holzmann C, Koczan D, Helmke BM, Bullerdiek J. Factors affecting the loss of MED12-mutated leiomyoma cells during in vitro growth. Oncotarget. 2017 May 23;8(21):34762-34772. doi: 10.18632/oncotarget.16711. PMID: 28410233; PMCID: PMC5471009.
  • Schmidt-Heck W, Wönne EC, Hiller T, Menzel U, Koczan D, Damm G, Seehofer D, Knöspel F, Freyer N, Guthke R, Dooley S, Zeilinger K. Global Transcriptional Response of Human Liver Cells to Ethanol Stress of Different Strength Reveals Hormetic Behavior. Alcohol Clin Exp Res. 2017 May;41(5):883-894. doi: 10.1111/acer.13361. Epub 2017 Mar 27. PMID: 28226195.
  • Friess J, Hecker M, Roch L, Koczan D, Fitzner B, Angerer IC, Schröder I, Flechtner K, Thiesen HJ, Winkelmann A, Zettl UK. Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis. Sci Rep. 2017 Feb 3;7:42087. doi: 10.1038/srep42087. PMID: 28155899; PMCID: PMC5290459.
  • Baufeld A, Koczan D, Vanselow J. Induction of altered gene expression profiles in cultured bovine granulosa cells at high cell density. Reprod Biol Endocrinol. 2017 Jan 5;15(1):3. doi: 10.1186/s12958-016-0221-6. PMID: 28056989; PMCID: PMC5217602.
  • Roch L, Hecker M, Friess J, Angerer IC, Koczan D, Fitzner B, Schröder I, Flechtner K, Thiesen HJ, Meister S, Winkelmann A, Zettl UK. High-Resolution Expression Profiling of Peripheral Blood CD8+ Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. Mol Neurobiol. 2017 Sep;54(7):5511-5525. doi: 10.1007/s12035-016-0075-0. Epub 2016 Sep 8. PMID: 27631876.